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Pharmaceutical and Bio-technology
Brief introduction
Ion exchange resin is widely used in pharmaceutical enterprises, such as desalination, adsorption separation, purification, decolorization, neutralization, and extraction of active ingredients from Chinese herbal medicines during the process of drug production. Mainly used for the extraction and purification of antibiotics, the extraction and separation of vitamins, and the purification of amino acids and proteins.
With the research and discovery of drug delivery system, ion exchange resin has been gradually used in the slow-controlled release drug delivery system and targeted drug delivery system, which mainly refers to the control of drug release rate in the gastrointestinal tract and the use of targeted delivery system as a carrier.

Resin can be used as pharmaceutical components and excipients, as well as water treatment agents, mainly used in the water treatment of pharmaceutical production process.

In the field of biotechnology, Bojie provides enzyme carrier resin to improve enzyme stability; Solid phase synthesis carrier for the synthesis of polypeptide drugs; Chromatography separation medium for preparation of various scales of biological macromolecules such as proteins, nucleic acids, polypeptides and polysaccharides.
Product

Antibiotic application-1

    Produt Name Typical Application Operation
    PC521 Recovering antibiotics from fermentation broth, extracting and refining heparin sodium
    PCM81 It is used for the purification of aminoglycoside antibiotics. Macrolactone antibiotics such as erythromycin, tylosin purified, erythromycin derivatives such as clarithromycin and azithromycin
    PC660 Lysozyme was extracted and aminoglycoside antibiotics including streptomycin, crossamycin and ipamidin were isolated
    PC821 Purification and decolorization of aminoglycoside antibiotics, decolorization of macrolide antibiotics, and recovery of clavulanic acid
    PC764 In the purification of cephalosporin C, it is often used in conjunction with BJ7505
    PC765 Purification of beta-lactam antibiotics
    PC165 Aminoglycoside antibiotics such as cisomicin, tobramycin and amikacin were extracted and enzyme was extracted
    PC941 For a variety of antibiotic extraction
    PC901 Extraction of oxytetracycline and other antibiotics
    PC912 It is suitable for the removal of cationic impurities in the production of various antibiotics such as gentamicin, streptomycin and oxytetracycline.
    PC916 Suitable for removing cationic impurities in the production of gentamicin, streptomycin, terramycin and other antibiotics
    PC640 It is suitable for the extraction of myxobacterin sulfate, streptomycin, gentamycin, neomycin and other antibiotics and lysomycin
    PC568 It is suitable for purification of streptomycin, oxytetracycline and other antibiotics

Antibiotic application-2

    Produt Name Moisture Content(%) Surface Area(m2/g) Typical Application Operation
    BJ7502 58-64 >550 Purification of antibiotics (such as cephalosporins, etc.), extraction of steroids, enzymes, peptides, etc.
    BJ7505 66-73 >700 Purification of antibiotics (such as cephalosporins.), steroid extraction.
    BJ7510 60-70 >800 Extraction and purification of antibiotics, water-soluble steroids (steroids), purification and recovery of antibodies
    BJ7507 55-65 >800 Purification of β-lactams and other small molecule antibiotics, steroid hormone extraction
    BJ7513 60-70 >400 Antibiotic, water-soluble steroid (steroid) purification, peptide and enzyme extraction
    BJ7514 65-73 >450 Insulin, antibiotic extraction
    BJ7506 55-65 >900 Drug extraction process; antibiotic purification (such as β-lactam antibiotics, cephalosporins, etc.), fermentation of antibiotics, carcasses and other substances.
    BJ7509 55-65 >600 Antibiotics, steroids and other substances were adsorbed in the fermentation broth, and antibiotics were purified.
    BJ7504 50-60 >550 Purification of antibiotics (e.g. beta-lactam antibiotics, cephalosporins, etc.), steroid hormone extraction
    BJ7520 55-65 >600 Antibiotic extraction: peptide purification

Vitamin application-1

    Product name Typical Application Operation
    PC165H Vitamin B12 extraction
    PCM91 Pantothenic acid (vitamin B5) extraction
    PCM82 Pantothenic acid (vitamin B5) extraction
    PC998 Suitable for refining and refining sorbitol, vitamin C, mannitol, etc.
    PCM83 Vitamin E purification

Vitamin application-2

    Product name Moisture Content(%) Surface Area(m2/g) Application Operation
    AB103 55-64 >1000 Vitamin E recovery
    BJ7508 58-65 >450 Vitamin B&E recycling
    BJ7512 55-65 >550 Vitamin E recovery
    BJ7506 55-65 >900 Recovering vitamins from fermentation broth
    BJ7502 58-64 >550 Extraction and separation of vitamins in fermentation broth

Amino acid application-1

    Product Name Typical Application Operation
    PC941 For the separation and extraction of a variety of amino acids
    PC901 For the separation and extraction of a variety of amino acids
    PC998 Suitable for lysine extraction and purification
    PC921 Suitable for the separation of many amino acids
    PCM94 Suitable for the separation and extraction of amino acids
    PC998B Amino acid extraction

Amino acid application-2

    Product name Moisture Content(%) Surface Area(m2/g) Typical Application Operation
    BJ7502 58-64 >550 Amino acid extraction
    BJ7505 66-73 >700 Amino acid recovery and purification
    BJ7510 60-70 >800 Amino acid recovery and purification
    BJ7507 55-65 >800 Amino acid recovery and purification
    BJ7513 60-70 >400 Amino acid recovery and purification
    BJ7504 50-60 >550 Amino acid extraction and separation

Protein application

    Product Name Moisture Content(%) Surface Area(m2/g) Typical Application Operation
    BJ7505 66-73 >700 Protein recovery and purification
    BJ7510 60-70 >800 Protein recovery and purification
    BJ7507 55-65 >800 Protein recovery and purification
    BJ7513 60-70 >400 Protein recovery and purification
    BJ7506 55-65 >900 Protein purification
    BJ7509 55-65 >600 Protein purification
    BJ7504 50-60 >550 Protein purification
    BJ7520 55-65 >600 Protein purification
    BJ7508 58-65 >450 Protein recovery and purification

Pharmaceutical application

    Product Name Typical Application Operation
    AP181Na For the treatment of hyperkalemia
    AP181Ca For the treatment of hyperkalemia
    AP181H It is used as carrier for sustained release, taste masking and dose stabilization. It is often used as a sustained-release carrier for codeine, dextromethorphan, narcotine and norephedrine.
    AP179 It can be used as an active ingredient and as a pharmaceutical carrier. It is a stabilizer for vitamin B12, and a sustained-release carrier for drugs such as nicotine.
    AP179K For high performance disintegrants
    AP268 Cholestyramine resin for the reduction of cholestyramine, taste masking, and sustained release. Also useful as a bile acid sequestrant
    AP195 Can be used for the treatment of excessive gastric acid secretion

Chromatograph

    Produt Name Ionic Form Moisture Content(%) Total Exchagne Capacity(eq/L) Particle Size(μm) Typical Application Operation
    PCG902 H 74-82 >0.6 150-300 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG903 H 74-82 >0.6 75-150 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG904 H 74-82 >0.6 40-75 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG942 H 64-72 >1.1 150-300 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG943 H 64-72 >1.1 75-150 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG944 H 64-72 >1.1 40-75 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG982 H 50-58 >1.7 150-300 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG983 H 50-58 >1.7 75-150 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG984 H 50-58 >1.7 40-75 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG822 Cl 70-80 >0.6 150-300 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG823 Cl 70-80 >0.6 75-150 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG824 Cl 70-80 >0.6 40-75 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG842 Cl 55-63 >1.0 150-300 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG843 Cl 55-63 >1.0 75-150 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG844 Cl 55-63 >1.0 40-75 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG882 Cl 39-45 >1.2 - 150-300 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG883 Cl 39-45 >1.2 - 75-150 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.
    PCG884 Cl 39-45 >1.2 - 40-75 Separation of pharmaceutically active ingredients: separation of similar components such as antibiotics, amino acids, nucleotides, etc.

Enzyme Carrier-Lipase

    Pruduct name Immobilization Moisture Content(%) Pore Diameter(A) Typical Application Operation
    ECR011 Adsorption 57-68 220-340 Suitable for lipase loading
    ECR012 Adsorption 67-78 200-300 Suitable for lipase loading
    ECR013 Adsorption 62-73 950-1200 Suitable for lipase loading
    ECR008 Adsorption 58-63 400-650 Suitable for most of the enzymes loading, more suitable for lipase and transaminase

Enzyme Carrier-Glycosidase

    Pruduct name Immobilization Typical Application Operation
    ECR101 Ionic The charged protein can interact with the ions in resin, suitable for the loading of glycosidase
    ECR102 Ionic The charged protein can interact with the ions in resin, suitable for the loading of glycosidase
    ECR103 Ionic The charged protein can interact with the ions in resin, suitable for the loading of glycosidase

Solid phase Synthesis Carrier

    Pruduct name Cross-linking Group load (mmol/g) Introduction Operation
    AM 1,2 0.5-3.0 Access to different peptides via amino groups
    Merrifield 1,2 0.5-2.0 Acidic peptide synthesis
    CTC 1,2 0.4-1.6 Better reactivity
    MBHA 1,2 0.3-1.5 Amino polypeptide synthesis
    Wang 1,2 0.5-3.0 Acidic peptide synthesis
    Benzyl alcohol 1,2 0.5-3.0 -
    Rink acid 1,2 0.3-1.2 -
    Rink amide 1,2 0.3-1.0 -
    Rink amide - MBHA 1,2 0.3-0.8 -
    Sulfonyl chloride 1,2 1.0-3.0 -

Protein separation Media

    Pruduct name Qianchun Polymer Matrix Structure Particle size(um) Introduction Operation
    Borose-A Purose 6FF Agarose 45-165 For separation of big biological molecules, such as: virus, DNA plasmid, etc.
    Borose-AQ Q Purose 6FF Agarose 45-165 Strong base anion exchange media. High applicationable, resolution, loading capacity
    Borose-ANi Ni-IDA Purose 6 FF Agarose 45-165 For separation and purification of His-Tag protein
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